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Oxaliplatin | 奥沙利铂 _ MedChemExpress (MCE)

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Oxaliplatin | 奥沙利铂

MCE 国际站:Oxaliplatin

中文名:奥沙利铂

CAS:61825-94-3

品牌:MedChemExpress (MCE)

存储条件:4°C, protect from light

生物活性:Oxaliplatin 是一种DNA 合成 抑制剂。 Oxaliplatin 引起 DNA 交联损伤,阻止 DNA 复制和转录并诱导细胞凋亡。奥沙利铂可用于癌症研究[1][2][3]。 IC50 和目标:IC50:DNA 合成[1]

体外:Oxaliplatin(24-72 小时;2-128 μM;HCC、HCCLM3 和 Hep3B 细胞)抑制细胞生长并诱导细胞凋亡[1]
Oxaliplatin(10 μM;15-240 分钟; CEM 细胞 ) 诱导原发性和继发性 DNA 损伤,包括 DNA 交联 (ISC) 和 DNA-蛋白质交联 (DPC)[2]
奥沙利铂(0.01 至 100 μM; 24 小时)有效抑制膀胱癌细胞系 RT4 和 TCCSUP、卵巢癌细胞系 A2780、结肠癌细胞系 HT-29、胶质母细胞瘤细胞系 U-373MG 和 U-87MG,以及黑色素瘤细胞系 SK-MEL-2 和 HT- 144 的 IC50 分别为 11 μM、15 μM、0.17 μM、0.97 μM、2.95 μM、17.6 μM、30.9 μM 和 7.85 μM[3]

体内:奥沙利铂(5-10 mg/kg;腹腔注射;32 天;裸鼠)抑制肿瘤生长[1]

热销产品:GNE-987 | L-DOPA | Adenine | Niraparib (tosylate) | Rosuvastatin (Calcium) | Caerulomycin A | Fagomine | Palmitic acid-13C16 | Canakinumab | BODIPY 576/589

研究领域:Cell Cycle/DNA Damage | Apoptosis

作用靶点:DNA/RNA Synthesis | Apoptosis

Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides

参考文献:

[1]. Raymond E, et al. Oxaliplatin: a review of preclinical and clinical studies. Ann Oncol. 1998 Oct;9(10):1053-71.

[2]. Mohammed MQ, et al. Oxaliplatin is active in vitro against human melanoma cell lines: comparison with NSC 119875 and NSC 241240. Anticancer Drugs. 2000 Nov;11(10):859-63.

[3]. Pendyala L, et al. In vitro cytotoxicity, protein binding, red blood cell partitioning, and biotransformation of oxaliplatin. Cancer Res. 1993 Dec 15;53(24):5970-6.

[4]. Wang Z, et al. Oxaliplatin induces apoptosis in hepatocellular carcinoma cells and inhibits tumor growth. Expert Opin Investig Drugs. 2009 Nov;18(11):1595-604

[5]. Mathé G, et al. Oxalato-platinum or 1-OHP, a third-generation platinum complex: an experimental and clinical appraisal and preliminary comparison with cis-platinum. Biomed Pharmacother. 1989;43(4):237-50.

[6]. Schellingerhout D, et al. Impairment of retrograde neuronal transport in oxaliplatin-induced neuropathy demonstrated by molecular imaging. PLoS One. 2012;7(9):e45776. doi: 10.1371/journal.pone.0045776. Epub 2012 Sep 20.

[7]. Park GY, et al. Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):11987-92.

[8]. Yi Yao, et al. Comparative proteomic analysis of colon cancer cells in response to oxaliplatin treatment. Biochim Biophys Acta. 2009 Oct;1794(10):1433-40.

[9]. Garrett MJ, et, al. Capecitabine, Oxaliplatin, and Bevacizumab (BCapOx) Regimen for Metastatic Colorectal Cancer. Hosp Pharm. 2017 May;52(5):341-347.

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